Complex approach in treatment of hypertension. Prevention of damage to target organs. Role and possibilities of cytoprotective therapy

Announcement:

We present to your attention a practice-oriented approach to the treatment of arterial hypertension from Professor Vadim Petrovich Mikhin . The expert review is devoted to modern views on the pathogenesis of arterial hypertension (AH) and strategies for complex therapy aimed not only at reducing blood pressure, but also at the real protection of target organs.

The video goes into detail about:

• Prevalence of hypertension and key treatment goals;
• How hypertension damages target organs;
• The role of endothelial dysfunction and vascular wall stiffness;
• Justification for the choice of first-line therapy according to clinical guidelines;
• Data from neurocytoprotection studies to improve therapy outcomes.

From this video you will learn:

• The scale of the problem: current data on the prevalence of hypertension in Russia among people over 35 years of age, which emphasizes the importance of the issue for every practicing physician.
• Key mechanisms of injury: a detailed analysis of the pathogenesis, including activation of free radical oxidation, endothelial dysfunction, vascular wall remodeling and the hypothesis of an autoimmune nature of hypertension.
• Visualization: you will see what healthy endothelium looks like and how it is transformed during dysfunction up to the formation of an atherosclerotic plaque.
• Treatment strategy according to recommendations: justification of the choice of first-line (ACE inhibitors/ARBs) and second-line (statins) drugs to influence key links in the pathological process.
• Clinical trial data: focus on the role of cytoprotective therapy using ethylmethylhydroxypyridine succinate as an example. Addition of this drug to standard therapy:
• Promotes reverse remodeling of the LV myocardium (reduction of the mass index);
• Improves diastolic function of the heart;
• • Increases LV ejection fraction (especially in combination with ACE inhibitors);
  • Reliably improves the functional activity of the vascular endothelium (according to the results of the cuff test);
  • Reduces the thickness of the intima-media complex of the carotid artery;
  • Improves the daily blood pressure profile, increasing the time the patient stays within target values.

  The video will be useful for all doctors who treat patients with cardiovascular pathology. Key conclusion: We don't just lower blood pressure, but protect blood vessels, heart and brain!